| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6276492 | Neuroscience | 2011 | 11 Pages |
Abstract
â¶Activation of the sigma receptor 1 suppresses NMDA currents in rat ganglion cells. â¶G-protein is associated with the modulation of NMDA currents by SKF. â¶PI-PLC/PKC pathway plays an important role in SKF-induced effect on NMDA currents. â¶PKA, PKG, PC-PLC pathways are not involved in the SKF effect.
Keywords
SKFmGluRIP3NMDAN-methyl-d-aspartatePLCIPLPKCDMSOinositol-1,4,5-triphosphateNMDA receptor[Ca2+]iNeurotransmissionG proteindiacylglycerolDimethyl sulfoxideDAGganglion cellGanglion cellsRetinaintracellular Ca2+ concentrationphosphatidylinositolphospholipase Cinner plexiform layerProtein kinase CSigma receptorMetabotropic glutamate receptor
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Authors
X.-J. Zhang, L.-L. Liu, S.-X. Jiang, Y.-M. Zhong, X.-L. Yang,