| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6276518 | Neuroscience | 2011 | 12 Pages |
Abstract
ⶠhMT1 mice are used to model the DYT1 dystonia carrier state. â¶hMT1 mice show increased metabolic activity in olivocerebellar structures. â¶Cytochrome oxidase activity is decreased in hMT1 striatum and pallidum. â¶The DYT1 carrier state shifts energy demand to the olivocerebellar network. â¶The inferior olive may be a central node for basal ganglia-olivocerebellar interactions.
Keywords
MGPlateral globus pallidusIOD2-deoxy-d-glucoseSubstantia nigra reticulataIOMSNRHWTSNCLGPO.D.CPuCCHEMROISTHRMCPCL2-DGVentral pallidumPCAGlucose utilizationMEDphosphate bufferPrincipal component analysisPositron emission tomographymedial globus pallidusdystoniainferior oliveLATPurkinje cellscytochrome oxidasePurkinje cell layerSubstantia nigra compactaregion of interestwild-typeventrolateral thalamic nucleusventromedial thalamic nucleuslateral cerebellar nucleusPontine nucleiSubthalamic nucleusCytochrome oxidase histochemistryPEToptical densityGlobus pallidus
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Authors
Y. Zhao, N. Sharma, M.S. LeDoux,