| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6276609 | Neuroscience | 2011 | 11 Pages |
Abstract
â¶Novel mechanism for Ca2+ signaling following oxidative stress in neuronal cell line. â¶Sublethal oxidative stress results in selective up-regulation of type-2 IP3 receptors. â¶Oxidative stress differentially mediates increased Ca2+ release into the nucleoplasm. â¶Novel source of Ca2+ dysregulation induced by oxidative stress. â¶Differential subcellular Ca2+ signaling specifically within the nucleus.
Keywords
HBSSinositol-1,4,5-trisphosphate receptortBHPRyRsIP3RDCFDAIP3PBS3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromideinositol-1,4,5-trisphosphateMTTROSacetoxymethylesterAlzheimer's diseaseNeurodegenerationcentral nervous systemendoplasmic reticulumPhosphate buffered salineNeuroprotectionHank’s balanced salt solutionNucleustert-butyl hydroperoxideCalciumReactive oxygen speciesRyanodine receptors
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Authors
S. Kaja, R.S. Duncan, S. Longoria, J.D. Hilgenberg, A.J. Payne, N.M. Desai, R.A. Parikh, S.L. Burroughs, E.V. Gregg, D.L. Goad, P. Koulen,