Possible involvement of syntaxin 1A downregulation in the late phase of allodynia induced by peripheral nerve injury

▶Syntaxin (STX) 1A is a membrane protein controlling synaptic exocytosis. ▶Peripheral nerve injury increased the frequency of mEPSCs in the spinal dorsal horn. ▶Peripheral nerve injury gradually decreased STX 1A expression in the dorsal horn. ▶STX 1A knockdown by an antisense ODN led to the gradual development of allodynia. ▶STX 1A might be involved in nerve injury-induced spinal nociceptive plasticity.