Sub-cellular distribution of UNC-104(KIF1A) upon binding to adaptors as UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2(Liprin-α) in C. elegans neurons

▶Interactome map identified putative adaptors and cargos for kinesin-3 UNC-104(KIF1A). ▶BiFC assay visualized protein complexes in the nervous system of living C. elegans. ▶For the first time direct interaction between kinesin-3 and dynactin/p150Glued shown. ▶Adaptor and precursor proteins regulate the allocation of UNC-104(KIF1A) in neurons. ▶Adaptor and precursor proteins also regulate UNC-104's motility in neurons.