| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6276669 | Neuroscience | 2011 | 10 Pages |
Abstract
â¶PDGF+FGF2 maintain oligodendrocyte progenitor cells (OLPs) in an immature state. â¶Activation of Erk signal is sufficient to maintain OLP in an immature state. â¶In OLP, Hes1 is induced by PDGF+FGF2 treatment via Erk signal. â¶Hes1 suppresses OLP maturation. â¶Erk negatively regulates OLP maturation by cell cycle progression and Hes1 induction.
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Neuroscience
Neuroscience (General)
Authors
T. Ogata, T. Ueno, S. Hoshikawa, J. Ito, R. Okazaki, K. Hayakawa, K. Morioka, S. Yamamoto, K. Nakamura, S. Tanaka, M. Akai,