Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6277569 | Neuroscience | 2009 | 15 Pages |
Abstract
The significant inter-individual variability in pain behavior and its contributing factors remains a pervasive clinical challenge and has generated intense scientific investigations in this field. Recent studies indicate that our genes considerably influence nociceptive information processes, how our nociceptive system copes with peripheral injury, and the individual response to analgesic treatments. Neuroimaging studies of pain are beginning to link such genetic influences with physiological processes in the human brain. This review presents the pioneering endeavors of the hybrid approach of neuroimaging pain genes in humans and identifies potential future directions.
Keywords
transient receptor potential cation channel, subfamily A, member 1GDNFSCN10APAGNGFCOMTRVMtransient receptor potential cation channel, subfamily V, member 1OPRM1Mc1rGTP cyclohydrolase 1Catechol-O-methyltransferaseGCH1CIPTRPV1TRPA1OPRD1BDNFNeuroimagingfunctional magnetic resonance imagingfMRIPositron emission tomographyCongenital insensitivity to painPeriaqueductal greyPainrostral ventromedial medullaGenesnerve growth factorGlial cell derived neurotrophic factorBrain-derived neurotrophic factorprimary somatosensory cortexSecondary somatosensory cortexpain modulationPETSingle nucleotide polymorphismSNPGeneticsMelanocortin 1 receptor
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
C. Ritter, U. Bingel,