| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6278466 | Neuroscience | 2007 | 9 Pages |
Abstract
Strategies for the generation of gene-targeted mice have been available for 15 years and more than 100 different genes relevant to DNA repair have been targeted. This review describes some important progress made toward understanding spontaneous DNA damage and its repair, exemplified through one, or a few, gene-targeted mice from each major DNA repair pathway.
Keywords
E. coliXRCCMutS homolog 28oxoGDNA ligase IIIXRCC2XPAXPCOGG1ABHMSH2MMRDSBBERSCENHEJTCr1-methyladenine3-methylcytosine8-oxoguanine8-oxoguanine DNA glycosylaseDNA ligase IVNERxeroderma pigmentosumEscherichia coliGGRHuntington diseaseSister chromatid exchangeDNA repairnucleotide excision repairmismatch repairbase excision repairbase pairdouble-strand breaknon-homologous end-joiningMouseknockoutHomologous recombinationERCC1
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Neuroscience (General)
Authors
L.M. Nordstrand, J. Ringvoll, E. Larsen, A. Klungland,