Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6278638 | Neuroscience | 2007 | 9 Pages |
Abstract
1) Following high-dose MDMA treatment sufficient to reduce SERT binding by 90%, a significant number of functionally intact 5-HT nerve terminals survive. 2) The degree of MDMA-induced decreases in SERT binding depends on the in vitro assay conditions. 3) 5-HTP-B restores brain 5-HT depleted by MDMA, suggesting that this approach might be clinically useful in abstinent MDMA users.
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Neuroscience (General)
Authors
X. Wang, M.H. Baumann, C.M. Dersch, R.B. Rothman,