Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6279095 | Neuroscience Letters | 2016 | 6 Pages |
Abstract
This study was aimed to evaluate effects of peptides from Phascolosoma esculenta and its ferrous-chelating peptides on spatial learning and memory in mice by Morris water maze test. 100Â mg/kg peptide on spatial learning and memory function about quadrant time and passing times through the platform better than 50 and 150Â mg/kg group during exploration period (PÂ <Â 0.05), without body weight between the weight and visual ability. 100Â mg/kg ferrous-chelating peptide group performed better ability of spatial learning and memory than 100Â mg/kg peptide group (PÂ <Â 0.05). qRT-PCR results showed that 50 and 100Â mg/kg administration peptide and 100Â mg/kg ferrous-chelating peptide can significantly improve mRNA expression of NR2A, NR2Â B and BDNF with oxidative stress status (GSH-Px, SOD, TAC and MDA), which explained mechanism for improving learning and memory ability in mice via anti-oxidative character.
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Authors
Lianliang Liu, Jinxuan Cao, Jiong Chen, Xin Zhang, Zufang Wu, Huan Xiang,