Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6279109 | Neuroscience Letters | 2016 | 6 Pages |
Abstract
Traumatic brain injury (TBI) is the leading cause of mortality and disability among male adolescents and young adults; and mild traumatic brain injury is the most common type of traumatic brain injury. The disruption of blood-brain barrier (BBB) plays an important role in brain trauma. Previously, we have found that slit2, a member of slit protein family, increases permeability of BBB. In the present study, we examined the role of slit2 in the pathogenesis of mild TBI in a mouse model of micro TBI. Rhodamine BandPI (PropidiumIodide) staining were used to detect the permeability of BBB and cell death, respectively. The leakage of Rhodamine B and cell death were significantly increased in Slit2-Tg mice than in C57 control mice after micro TBI. The present results suggest that over expression of slit2 plays a detrimental role in the pathophysiology of mild TBI.
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Authors
Shuai Li, Hang Li, Xiao-fei He, Ge Li, Qun Zhang, Feng-ying Liang, Huan-huan Jia, Jiang-chao Li, Ren Huang, Zhong Pei, Li -jing Wang, Yu Zhang,