Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6279509 | Neuroscience Letters | 2016 | 18 Pages |
Abstract
This wheel-running assay allows one to compare the neurotoxic potency of different volumes and doses of the BoNT products in vivo. Our results argue against common clinical practice because incobotulinumtoxinA and onabotulinumtoxinA are not readily interchangeable and a two-fold dose of abobotulinumtoxinA is needed to induce an effect identical to onabotulinumtoxinA. In addition, this emphasizes that the duration of BoNT-induced effect is the same as long as equipotent doses of BoNT are injected.
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Neuroscience
Neuroscience (General)
Authors
Anna Kutschenko, Anja Manig, Marie-Christine Reinert, Angelika Mönnich, David Liebetanz,