Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6279795 | Neuroscience Letters | 2016 | 7 Pages |
Abstract
The simultaneous role of neuroprotective estrogen and neurodegenerative inflammation during the progression of Parkinson's disease (PD) is still remaining elusive. The novel importance of the present study in MPTP mediated mouse model of Parkinson's disease (PD) is-to investigate the status of neuronal and glial cells in a time chase experiment; to explore which pathway of NF-kappaB exist to proceed the neuroinflammation; to investigate the status of estrogen and the activation pattern of nuclear or cytosolic estrogen receptors in either sexes of Swiss albino mice during MPTP mediated progressive neurodegeneration in the substantia nigra. After MPTP intoxication, the nigral molecular anatomy was changed differently in separate time interval during the progression of neurodegeneration with/without association of glial cells and functional (via its nuclear and cytosolic receptors) estrogen level. Both the canonical and/or non-canonical pathways of NF-kappaB exist in the substantia nigra of both the sexes after MPTP treatment that is why inspite of presence of estrogen, neuroinflammation progresses. The homodimeric or heterodimeric form of ER-beta binds with NF-kappaB molecules p65 and RelB differently, but the canonical or non-canonical pathways of NF-kappaB molecules could not be stopped or may be promoted.
Keywords
NF-κBIBA11-methyl-4-phenylpyridiniumGFAPMPTPb.w.1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineMPP+AstrocyteEstrogenParkinson's diseasesubstantia nigratumor necrosis factor-alphaTNF-αnuclear factor kappa Bionized calcium binding adaptor molecule 1Microgliabody weightGlial fibrillary acidic proteinEstrogen receptor
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Authors
Soham Mitra, Nabanita Ghosh, Priyobrata Sinha, Nilkanta Chakrabarti, Arindam Bhattacharyya,