| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6279985 | Neuroscience Letters | 2016 | 4 Pages |
Abstract
The Ca2+-dependent activator protein for secretion 1 (CAPS1) protein plays a regulatory role in the dense-core vesicle exocytosis pathway. To clarify the functions of this protein in the brain, we searched for novel interaction partners of CAPS1 by mass spectrometry. We identified a specific interaction of CAPS1 with septin family proteins. We also demonstrated that the C-terminal region of the CAPS1 protein binds to part of the deduced GTP-binding domain of septin proteins. It is possible that a tertiary complex of septin, CAPS, and syntaxin contributes to dense-core vesicle trafficking and exocytosis in neurons.
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Authors
Mayu Hosono, Yo Shinoda, Touko Hirano, Yasuki Ishizaki, Teiichi Furuichi, Tetsushi Sadakata,