| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6280313 | Neuroscience Letters | 2015 | 6 Pages |
Abstract
This study analyzes immune reactivity in two lines of rats selected for the enhancement or elimination of aggressiveness toward humans. Compared to nonaggressive line, aggressive rats showed increased blood ratio of CD4+ and CD8+T lymphocytes, monocyte chemoattractant protein (MCP)-1 level both before and after immunization with sheep red blood cells (SRBC), enhanced IgM-immune response, as well as decreased level of interleukin (IL)-1α before immunization. However, antigen administration produced IL-1α increase in aggressive rats and its decrease in nonaggressive rats compared to non-immunized rats of the same lines. In addition, line-dependent alterations of T lymphocyte distribution in response to immune activation have been found only in the spleen. It is suggested that genetic differences in aggressive behavior may contribute to differences in immune function.
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Neuroscience
Neuroscience (General)
Authors
Galina Idova, Elizaveta Alperina, Irina Plyusnina, Margarita Gevorgyan, Elena Zhukova, Maria Konoshenko, Rimma Kozhemyakina, Wang Shui-Wu,