Effects of curcumin on TTX-R sodium currents of dorsal root ganglion neurons in type 2 diabetic rats with diabetic neuropathic pain

Article ID	Journal	Published Year	Pages	File Type
6280647	Neuroscience Letters	2015	19 Pages	PDF

Abstract

- The DNP model was established based on type 2 diabetic rats.
- TTX-R sodium currents were recorded from small-sized DRG neurons.
- The TTX-R sodium currents of DNP rats were significantly increased.
- Curcumin could ameliorate the hyperalgesia and reduce the TTX-R sodium currents of DNP rats.

Keywords

DRG MWT HFD TTX STZ RMP DNP VGSCs TWL Mechanical Withdrawal Threshold T2DM dorsal root ganglion INa ISI Streptozocin tetrodotoxin Sodium currents Diabetic neuropathic pain Type 2 diabetic mellitus thermal withdrawal latency Insulin sensitivity index resting membrane potential voltage-gated sodium channels Curcumin