Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6281835 | Neuroscience Letters | 2014 | 5 Pages |
Abstract
Brain-derived neurotrophic factor (BDNF) plays a pivotal role in memory consolidation. Previously, we found that the increased mature BDNF (mBDNF) levels in the hippocampal region at a specific time window after the acquisition trial are required for memory consolidation. In the present study, we investigated whether spicatoside A enhances memory consolidation, and whether its effects on memory consolidation are related to hippocampal mBDNF levels. Spicatoside A (2.5, 5, 10 or 20Â mg/kg) enhanced memory consolidation in a dose-dependent manner, and enhanced memory consolidation was also observed when spicatoside A was administered 1Â h after the acquisition trial. Concurrently, when spicatoside A was administered immediately or 1Â h after the acquisition trial, hippocampal mBDNF levels were similar or significantly increased at 9Â h after the acquisition trial compared to levels at 6Â h. These results suggest that increased mBDNF levels in the hippocampal region at 9Â h after the acquisition trial might play a pivotal role in memory consolidation and that spicatoside A might enhance memory consolidation by increasing hippocampal mBDNF levels.
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Authors
Guyoung Kwon, Hyung Eun Lee, Dong Hwa Lee, Hyun Woo, Se Jin Park, Qingtao Gao, Young Je Ahn, Kun Ho Son, Jong Hoon Ryu,