Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6281907 | Neuroscience Letters | 2014 | 5 Pages |
â¢APOE É4 alleles contributed detrimental effects on cognitive function in the very old Chinese male without dementia.â¢Cognitive function impairment, especially executive abilities may be more profound among very elderly non-demented population.â¢Asian population may be more vulnerable to the É4 allele detrimental effect on cognition.
Apolipoprotein E (APOE) gene polymorphism has been reported to be associated with cognitive dysfunction in healthy individuals, however the results were controversial in the very old elderly. The aim of this study is to assess the possible association of the APOE polymorphism with cognitive dysfunction in people aged 75 years and over. Four hundred and twenty-five aged Chinese veteran men without dementia were enrolled for APOE genotyping and neuropsychological tests including Mini-Mental Status Examination (MMSE), Digit Span Forward and Backward, and Cognitive Ability Screening Instrument Chinese language version (CASI C-2.0) were evaluated in these subjects. Among the elderly veterans, people who carry APOE É4 were found to have worse performance on the total CASI scores, the abstraction/judgment subscores and the list-generating fluency subscores. This study suggests that the APOE É4 alleles contributed detrimental effects on cognitive function in the very old veterans who do not have dementia.