| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6281991 | Neuroscience Letters | 2014 | 6 Pages |
Abstract
- Divalent metal ions augment DOPAL-induced oligomerization of alpha-synuclein.
- Valency, not redox state, determines the augmentation of oligomerization.
- Dopamine and deaminated metabolites besides DOPAL do not oligomerize synuclein.
- Anti-oxidant treatment or divalent ion chelation attenuates metal ion effect.
- Cu2+ augments DOPAL-induced dimerization of alpha-synuclein in PC12 cells.
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Authors
Yunden Jinsmaa, Patricia Sullivan, Daniel Gross, Adele Cooney, Yehonatan Sharabi, David S. Goldstein,