Myelinated Ah-type trigeminal ganglion neurons in female rats: neuroexcitability, chemosensitivity to histamine, and potential clinical impact

Myelinated Ah-type trigeminal ganglion neurons are observed except for myelinated A- and unmyelinated C-types (upper left figures). These myelinated Ah-type trigeminal ganglion neurons highly respond to histamine (upper right figures). The myelinated Ah-type trigeminal ganglion neuron demonstrates higher neuroexcitability because of functional expression of persistent TTX-R Na+ channel currents (central panel figures) and large conductance Ca2+-activated-K+ channel currents (lower panel figures).