| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6282833 | Neuroscience Letters | 2013 | 5 Pages |
Abstract
Adrenomedullin (AM), a member of the calcitonin gene-related peptide (CGRP) family, has been demonstrated to be a pronociceptive mediator. This study was undertaken to investigate the role of AM in acute inflammatory pain induced by formalin injection in rats. Interestingly Cerebrospinal fluid (CSF) levels of AM increased 45Â min after formalin injection and a selective AM receptor antagonist, AM22-52, administered intrathecally (i.t.) decreased phase 2 flinching in a dose-dependent manner but not phase 1 flinching during the formalin test. This anti-hyperalgesic effect of i.t. AM22-52 lasted for 4Â h or more. AM in the CSF contributes to the modulation of acute inflammatory pain in the formalin test, and blocking downstream signaling effects of the AM receptor has the potential to relieve pain associated with acute inflammation.
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Authors
Yuki Sugimoto, Seiji Shiraishi, Toshimichi Yasuda, Hiroshi Hamada, Masashi Kawamoto,