| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6282881 | Neuroscience Letters | 2013 | 6 Pages |
Abstract
In the present work I investigate the regulation of SC1/PRMT5-mediated methylation activity in PC12 cells treated with EGF or NGF. I present evidence that NGF down-regulates SC1/PRMT5 methyltransferase (MTase) activity and that the reduction in SC1/PRMT5 MTase activity occurs mainly in the nucleus. I suggest that high levels of SC1/PRMT5 activity are associated with the proliferative state of the cells.
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Neuroscience
Neuroscience (General)
Authors
Alexandra Chittka,