Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6282972 | Neuroscience Letters | 2013 | 5 Pages |
Abstract
Systemic administration of S18986, a positive allosteric modulator of AMPA receptors, improves cognition. The present study further characterizes the drug's memory-enhancing properties and is the first to investigate its intracerebral effects on learning and memory. The results showed that rats receiving a single dose of S18986 (3 μg/site) into the prelimbic cortex, prior to olfactory discrimination acquisition, exhibited significantly shorter latencies and fewer errors to make the correct response, both in the acquisition and two drug-free retention tests. Such findings corroborate the involvement of glutamate receptors in odor-reward learning and confirm the role of the AMPAkine S18986 as a cognitive enhancer.
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Authors
Natalya Yefimenko, Marta Portero-Tresserra, Margarita MartÃ-Nicolovius, Gemma Guillazo-Blanch, Anna Vale-MartÃnez,