Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6283227 | Neuroscience Letters | 2013 | 6 Pages |
Abstract
The present study investigated the effect of early life stress in adolescent rats on brain metabolites, serum corticosterone, and depressive-like behavior. A group of rats was subject to early life stress from postnatal day (PND) 1 to 14. A matched control group was studied. Behavioral tests, serum corticosterone and high-resolution proton magnetic resonance spectroscopy were conducted between PND 30 and 40. In this study, adolescent rats exposed to early life stress demonstrated depressive-like behavior and increased serum corticosterone during adolescence. They also showed reduced glutamate, glutamine, and N-acetylaspartate (NAA) levels in the prefrontal cortex. A reduced myo-inositol level, consistent with astroglial deficits, was observed but was not statistically significant. Together, these findings characterize the effect of early life stress on adolescent animals and underscore the long-lasting and detrimental effects of childhood adversities.
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Authors
Jie Zhang, Chadi G. Abdallah, Yaowen Chen, Tianhua Huang, Qingjun Huang, Chongtao Xu, Yeyu Xiao, Yuzhen Liu, Yan Ding, Renhua Wu,