| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6283316 | Neuroscience Letters | 2013 | 4 Pages |
Abstract
The analysis of interictal epileptiform discharges (IEDs) using magnetoencephalography (MEG) is utilized for the localization of seizure onset zones in the presurgical planning of epilepsy patients. Additionally, resting-state functional connectivity analyses using the IED area may provide novel insight into the underlying brain networks. In this study, we evaluate whether chronicity of seizures is related to whole-brain functional connectivity metrics using the area of IED generation (derived from MEG) as the seed region. We found a positive correlation between the duration of seizures and beta-band functional connectivity between the epileptogenic zone and other brain areas. This suggests the presence of inhibitory GABAergic modulation of distal brain regions in response to chronic epileptiform activity.
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Authors
Deepak Madhavan, Elizabeth Heinrichs-Graham, Tony W. Wilson,