| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6283328 | Neuroscience Letters | 2013 | 5 Pages |
Abstract
⺠We performed case-control analyses of low frequency genetic variants in OPRM1 in drug addicted individuals. ⺠1377 European Americans and 1238 African Americans addicted to heroin or cocaine were genotyped for 4 SNPs in OPRM1. ⺠One SNP, rs rs62638690, was significantly associated with cocaine and/or heroin addiction in European Americans. ⺠Previous studies have found this SNP to reduce the potency of the μ-opioid receptor for opioids.
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Toni-Kim Clarke, Richard C. Crist, Kyle M. Kampman, Charles A. Dackis, Helen M. Pettinati, Charles P. O'Brien, David W. Oslin, Thomas N. Ferraro, Falk W. Lohoff, Wade H. Berrettini,