Use of sodium bicarbonate to promote weight gain, maintain body temperature, normalize renal functions and minimize mortality in rodents receiving the chemotherapeutic agent cisplatin

- NaHCO3 simple method to reduce adverse renal effects of repeated cisplatin treatment.
- NaHCO3/cisplatin show weight gain, normal temperature, creatinine and kidney ratio.
- Saline/cisplatin show lower weight and temperature, higher creatinine and kidney ratio.
- Pretreatment with either Saline or NaHCO3 does not prevent cisplatin- induced neuropathy.
- NaHCO3 pretreatment induce good health and normal creatinine levels and kidney ratio.