Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6283361 | Neuroscience Letters | 2013 | 5 Pages |
Abstract
Large-scale genome-wide association studies (GWAS) identified BIN1 gene rs744373 polymorphism to be significantly associated with Alzheimer's disease (AD) in Caucasian ancestry. Recently, this polymorphism was also investigated in East Asian population. However, no study reported significant association. We consider that the failure to replicate significant association between rs744373 polymorphism and AD may be caused by the relatively small sample size. In this research, we evaluated this association using pooled samples from previous studies (n = 4982, 1437 AD cases and 3545 controls). Two methods including pooled analysis and meta-analysis were used to investigate the association. Using the pooled analysis, we observed significant association between rs744373 polymorphism and AD by both genotype test (P = 3.94Eâ03, 4.59Eâ03 and 1.04Eâ02) and allele test (P = 1.12Eâ03, OR = 1.16, 95% CI 1.06-1.28). Interestingly, the meta-analysis confirmed this association with P = 8.00Eâ03 (OR = 1.14, 95% CI 1.03-1.25) and P = 2.00Eâ02 (OR = 1.16, 95% CI 1.02-1.32). We also evaluated the effect of rs744373 polymorphism on AD risk in different ethnic backgrounds and found that rs744373 polymorphism contributed to AD with similar genetic risk in East Asian and Caucasian populations. To our knowledge, this is the first study to show significant association between rs744373 polymorphism and AD in East Asian population.
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Authors
Guiyou Liu, Shuyan Zhang, Zhiyou Cai, You Li, Lili Cui, Guoda Ma, Yongshuai Jiang, Liangcai Zhang, Rennan Feng, Mingzhi Liao, Zugen Chen, Bin Zhao, Keshen Li,