| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6283402 | Neuroscience Letters | 2013 | 5 Pages |
Abstract
The aim of this study was to find out the effect of low-level laser therapy (LLLT) on salicylate-induced tinnitus in the rat model. Fourteen Sprague-Dawley rats (8 weeks; 240-280Â gm) were divided into 2 groups (study group, control group). Rats of both groups were treated with 400Â mg/kg/day of sodium salicylate for 8 consecutive days. Tinnitus was monitored using GPIAS (Gap Prepulse Inhibition of Acoustic Startle) 2Â h after first salicylate treatment, and every 24Â h during 9 days of treatment. Rats in laser group were irradiated to each ear with wavelength of 830Â nm diode laser (165Â mW/cm2) for 30Â min daily for 8 days. During salicylate treatment, rats of study group irradiated with low level laser showed significantly higher GPIAS values throughout the experiment. Therapeutic effect of LLLT is demonstrated in animal tinnitus model by means of GPIAS. Further experimental studies are needed to find possible mechanisms and better methods to improve LLLT efficacy.
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Life Sciences
Neuroscience
Neuroscience (General)
Authors
Young Min Park, Woo Sung Na, Il Yong Park, Myung-Whan Suh, Chung-Ku Rhee, Phil-Sang Chung, Jae Yun Jung,