| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6283493 | Neuroscience Letters | 2013 | 6 Pages |
Abstract
⺠COMT (rs4680) and MTHFR (rs1801133) enzyme genes are related with cognition. ⺠Their interaction in schizophrenia has not been adequately investigated. ⺠It is unknown whether dopamine interacts with methylation mechanisms on cognition. ⺠We found that COMT and MTHFR interacted on working memory and planning. ⺠MTHFR hypofunction likely attenuates the cognitive effects of COMT hyperfunction.
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Authors
Dimitrios Kontis, Eirini Theochari, Helen Fryssira, Spyridon Kleisas, Christalena Sofocleous, Angeliki Andreopoulou, Stamatina Kalogerakou, Anthia Gazi, Lucia Boniatsi, Alexandros Chaidemenos, Eleftheria Tsaltas,