Article ID Journal Published Year Pages File Type
6283498 Neuroscience Letters 2013 4 Pages PDF
Abstract
► Ethanol induces amnesia via inhibition of LTP, a form of synaptic plasticity. ► In this study, 4-methylpyrazole was used as an alcohol dehydrogenase inhibitor. ► 4-Methylpyrazole allowed LTP in the presence of ethanol. ► Local metabolism to acetaldehyde may contribute to the ethanol-mediated amnesia.
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Life Sciences Neuroscience Neuroscience (General)
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Locally-generated acetaldehyde is involved in ethanol-mediated LTP inhibition in the hippocampus
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