| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6283500 | Neuroscience Letters | 2013 | 6 Pages |
Abstract
⺠CD133+ cells coexpress higher levels of ADAM17 in both U87 glioblastoma stem cells (GSCs) and primary human glioma samples. ⺠ADAM17 blockade depletes CD133-positive cells and inhibits neurosphere formation in GSCs. ⺠ADAM17 inhibition induces GSCs neurosphere differentiation. ⺠ADAM17 knockdown decreases Notch signaling pathway activation.
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Authors
Xiangrong Chen, Lei Chen, Run Zhang, Yongjun Yi, Yabin Ma, Ke Yan, Xiaodan Jiang, Xiangyu Wang,