| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6283556 | Neuroscience Letters | 2013 | 6 Pages |
Abstract
⺠Transport of drugs by the choroid plexus (CP) is believed to be an important factor in regulating CNS drug levels. ⺠The organic anion transporters Oat1 (SLC22A6) and Oat3 (SLC22A8), as well as SLC22A17, are highly expressed in CP. ⺠Ex vivo transport of antivirals used for HIV and other diseases was studied in CP from Oat1 and Oat3 knockouts. ⺠Zidovudine, acyclovir, tenofovir and lamivudine were shown to interact with both Oat1 and Oat3. ⺠Specific inhibitors of Oat1 and Oat3 may be helpful in altering CNS drug levels by blocking Oat function in the CP.
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Authors
Megha A. Nagle, Wei Wu, Satish A. Eraly, Sanjay K. Nigam,