Article ID Journal Published Year Pages File Type
6283601 Neuroscience Letters 2013 5 Pages PDF
Abstract

Occlusal disharmony is associated with increased plasma corticosterone levels, learning deficits, and morphologic alterations in the hippocampus via chronic stress. Here, we investigated the occlusal disharmony-induced impairment of hippocampal function. We first examined the effects of raising the bite on newborn cell proliferation in the hippocampal dentate gyrus (DG) in senescence-accelerated prone mice. Raising the bite significantly decreased cell proliferation in the hippocampal DG in an age-dependent manner. Immediately after raising the bite, cell proliferation decreased abruptly in the aged mice, then gradually increased, but did not recover to control levels within 2 wk. Further, learning-induced cell proliferation was impaired in aged bite-raised mice. These findings suggest that occlusal disharmony induced by raising the bite impaired cell proliferation in the hippocampal DG, leading to learning deficits.

► Effects of bite-raising on hippocampalcell proliferation are not known. ► Raising the bite suppresses cell proliferation in the hippocampus. ► Cell proliferation in bite-raised mice did not recover control levels within 2 wk. ► Raising the bite blocked increases in learning-induced cell proliferation. ► Bite-raising suppressed of cell proliferation, leading to spatial learning deficits.

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