Contribution of the spinal microglia to bee venom-induced inflammatory pain in conscious rats

It is well known that spinal glia plays a key role in the pathogenesis of pain. The present study was designed to determine the roles of spinal microglia in bee venom-induced persistent spontaneous nociception (PSN), mechanical hyperalgesia and inflammation. We determined the effects of microglia inhibitor minocycline on BV-induced PSN, mechanical hyperalgesia and inflammatory swelling. Pre-treatment with intrathecal administration of minocyline at different doses significantly inhibited BV-induced PSN and mechanical hyperalgesia, but had no effect on BV-induced inflammatory swelling. These data suggest that the activation of spinal microglia may play a key role in BV-induced nociception, but not inflammation.

► Spinal microglia inhibitor inhibited bee venom-induced persistent spontaneous nociception and mechanical hyperalgesia. ► Spinal microglia inhibitor had no effect on bee venom-induced inflammatory edema. ► Spinal microglia may contribute to bee venom-induced nociception, but not inflammation.