| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6283676 | Neuroscience Letters | 2013 | 6 Pages |
Abstract
⺠Efficacy of microglial NTN delivery for Parkinson's disease gene therapy is tested. ⺠Gene modified bone marrow-derived microglia accumulate in diseased sites. ⺠Microglial NTN delivery dramatically reduces degeneration of dopaminergic neurons. ⺠Protected dopaminergic terminals in the striatum, and restored motor deficits. ⺠No apparent major side effects were observed.
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Authors
K.C. Biju, Rene A. Santacruz, Cang Chen, Qing Zhou, Jiemin Yao, Sara L. Rohrabaugh, Robert A. Clark, James L. Roberts, Kimberley A. Phillips, Syed Z. Imam, Senlin Li,