| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6283696 | Neuroscience Letters | 2013 | 5 Pages |
Abstract
⺠Cells expressing amyloid precursor protein (APP) or a combination of APP and presenilin show significant mortality. ⺠Nicotine dose dependently attenuated cell loss with highest sensitivity in doubly transfected cells. ⺠Nicotine's effect was blocked by mecamylamine with differential sensitivity in different cell lines. ⺠The results support therapeutic potential for nicotinic agonists in at least a subtype of AD.
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Authors
Dwayne Brown, Carlana Ramlochansingh, Kebreten F. Manaye, Yousef Tizabi,