Ligand binding of PDZ domains has various roles in the synaptic clustering of SAP102 and PSD-95

Article ID	Journal	Published Year	Pages	File Type
6283785	Neuroscience Letters	2013	6 Pages	PDF

Abstract

âº Ligand binding-deficient PDZ domains enhance the synaptic clustering of SAP102. âº PDZ domains play distinct roles in the synaptic clustering of SAP102 and PSD-95. âº Binding of NMDAR with SAP102 is required for its efficient synaptic clustering.

Keywords

PBS PSD eGFP SAP102 VGLUT AMPA PDZ α-amino-3-hydroxy-5-methylisoxazole-4-propionate PSD-95 membrane-associated guanylate kinase NMDA receptor MAGUK postsynaptic density vesicular glutamate transporter Synaptic clustering PDZ domain DIV day in vitro sci Phosphate-buffered saline enhanced green fluorescent protein postsynaptic density protein-95