Induction of methionine sulfoxide reductase activity by pergolide, pergolide sulfoxide, and S-adenosyl-methionine in neuronal cells

Article ID	Journal	Published Year	Pages	File Type
6283805	Neuroscience Letters	2013	4 Pages	PDF

Abstract

âº Methionine sulfoxide reductase (Msr) is upregulated in neurons by small compounds. âº Msr activity is upregulated upon treatment with pergolide and pergolide sulfoxide. âº Msr activity is upregulated upon treatment with S-adenosyl-methionine. âº The compound-mediated upregulated Msr activity may alleviate neuronal malfunction.

Keywords

MSR SAM MetO Pergolide S-adenosyl methionine S-adenosyl-methionine Antioxidants post-translational modification Oxidative stress Methionine sulfoxide methionine sulfoxide reductase Signal transduction