| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6283830 | Neuroscience Letters | 2012 | 6 Pages |
Abstract
⺠A trigeminal neuropathic pain model was used with inferior alveolar nerve transection. ⺠IL-18 upregulation occurred in hyperactive microglia in the trigeminal spinal subnucleus caudalis. ⺠IL-18 was increased in the Vc around obex area from 3 d until 14 d after nerve injury. ⺠IL-18 induction coexisted with phosphorylated p38 MAPK. ⺠The findings suggest a role of IL-18 in orofacial neuropathic pain mechanism.
Keywords
GFAPp-p38Trigeminal spinal subnucleus caudalisIL-18IL-1βIBA1IANImmunoreactivityInterleukin-18Interleukin-1βtumor necrosis factor-αNeuropathic painProinflammatory cytokinedorsal horninferior alveolar nervetrigeminal nerveTNF-αionized calcium-binding adapter molecule 1MicrogliaGlial fibrillary acidic protein
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Authors
Erina Daigo, Yasushi Sakuma, Kan Miyoshi, Koichi Noguchi, Junichiro Kotani,