Dexmedetomidine decreases hyperalgesia in neuropathic pain by increasing acetylcholine in the spinal cord

Article ID	Journal	Published Year	Pages	File Type
6283844	Neuroscience Letters	2012	5 Pages	PDF

Abstract

âº Interaction between Î±2-adrenergic and acetylcholine in neuropathic pain was examined. âº Spinal Î±2-adrenoceptor activation suppressed hyperalgesia in rats with nerve injury. âº The anti-hyperalgesia was reversed by an intrathecal muscarinic receptor antagonist. âº Spinal Î±2-adrenoceptor activation increased acetylcholine in rats with nerve injury. âº Acetylcholine contributes to analgesia from spinal Î±2-adrenoceptor activation.

Keywords

α2-Adrenoreceptor Acetylcholine Neuropathic pain Donepezil Dexmedetomidine Spinal cord