| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6283918 | Neuroscience Letters | 2012 | 5 Pages |
Abstract
⺠The γ-secretase inhibitor DAPT perturbed Aβ production like clinical presenilin mutations. ⺠Lipidomics protocol for neuritic terminals of PC12 cells was established. ⺠The γ-secretase inhibitor DAPT increased the gangliosides at neuritic terminals.
Keywords
γ-SecretaseESIGangliosideAβMRMNGFUPLCAPPnanoESIMS/MSamyloid β-proteinAlzheimer diseaseMass spectrometryTandem mass spectrometrynerve growth factorLipidomicsmultiple reaction monitoringPresenilinβ-amyloid precursor proteinliquid chromatographyLiquid chromatography/electrospray ionization tandem mass spectrometryUltraperformance liquid chromatographyelectrospray ionization
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Authors
Naoto Oikawa, Miho Goto, Kazutaka Ikeda, Ryo Taguchi, Katsuhiko Yanagisawa,