Chrysotoxine, a novel bibenzyl compound selectively antagonizes MPP+, but not rotenone, neurotoxicity in dopaminergic SH-SY5Y cells

Article ID	Journal	Published Year	Pages	File Type
6283945	Neuroscience Letters	2012	6 Pages	PDF

Abstract

âº Chrysotoxine selectively antagonizes MPP+ but not rotenone toxicity in SH-SY5Y cells. âº Chrysotoxine inhibits MPP+-induced ROS overproduction and mitochondria dysfunction. âº Chrysotoxine inhibits MPP+-induced NF-ÎºB activation. âº Chrysotoxine modulates anti-apoptotic and pro-survival signals.

Keywords

6-Hydroxydopamine phosphoinositide 3-OH kinase DMEM/F-12 Rh123 dopamine-β-hydroxylase ΔΨm MPTP DAT DCFH-DA HRP DBH NF-κB PI3K FBS 6-OHDA 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-Methyl-4-phenyl pyridinium 2,7-dichlorofluorescein diacetate DMSO MAPK Mitogen activated protein kinases MPP+MTT ROS [Ca2+]i Akt Mitochondrial dysfunctions Dopamine transporter Parkinson's disease tyrosine hydroxylase Dimethyl sulfoxide Rotenone fetal bovine serum intracellular calcium concentration lactate dehydrogenase LDH Mitochondrial membrane potential Horseradish peroxidase Reactive oxygen species