| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6283995 | Neuroscience Letters | 2012 | 5 Pages |
Abstract
⺠The role of the purinergic receptors for the neuronal differentiation was examined. ⺠The P2Y13 receptor antagonist MRS2211 significantly accelerated neurite outgrowth. ⺠The P2Y13 further increased the NGF-induced activation of ERK1/2 in PC12 cells. ⺠P2Y13 receptor seem to be involved in suppression of neuronal differentiation. ⺠P2Y13 receptor antagonists might be candidates for treatment of neurodegenerative diseases.
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Authors
Shinya Yano, Mitsutoshi Tsukimoto, Hitoshi Harada, Shuji Kojima,