Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6283998 | Neuroscience Letters | 2012 | 4 Pages |
Abstract
⺠Mutations in the EIF4G1 gene have been found in patients with Parkinson's Disease (PD) [2]. ⺠We investigate the mutations in a familial PD cohort and in sub-Saharian Africans and Europeans. ⺠We failed to identify any mutation in the PD cohort. We identify the p.A502V (previously associated to PD) in Caucasians. ⺠Mutations in the EIF4G1 gene are a very rare cause of PD in European individuals. ⺠The protein can tolerate some extent of genetic variability.
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Neuroscience
Neuroscience (General)
Authors
Arianna Tucci, Gavin Charlesworth, Una-Marie Sheerin, Vincent Plagnol, Nicholas W. Wood, John Hardy,