Nicotine modifies in vivo and in vitro rat hippocampal amyloid precursor protein processing in young but not old rats

Article ID	Journal	Published Year	Pages	File Type
6284048	Neuroscience Letters	2012	5 Pages	PDF

Abstract

âº Chronic nicotine infusions increased particulate APP in the rat hippocampus in vivo. âº This in vivo response to nicotine was age and regionally selective. âº In vitro, nicotine stimulated the release of secreted APP from hippocampal slices. âº The in vitro effect of nicotine on APP was age-related.

Keywords

Aβ AChR PDBu Secreted amyloid precursor protein Apps Alzheimer's disease Age phorbol 12,13-dibutyrate Nicotine Hippocampus Amyloid-beta protein amyloid precursor protein acetylcholine receptor