| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6284059 | Neuroscience Letters | 2012 | 6 Pages |
Abstract
⺠We studied long-term hippocampal glial activation in a pilocarpine rat model. ⺠A epileptogenic dose and its fractions were applied. ⺠Morphology and density of astrocytes and microglia were evaluated at 2, 4, 8 weeks. ⺠Astrocyte peak-hypertrophy and trough-density values correlated to epileptogenesis. ⺠Data indicate glial resilience loss plays a key role in delayed epileptogenesis.
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Authors
Felipe S. Estrada, Vito S. Hernández, Estela López-Hernández, Aleph A. Corona-Morales, Hugo SolÃs, Alfonso Escobar, Limei Zhang,