Article ID Journal Published Year Pages File Type
6284069 Neuroscience Letters 2012 4 Pages PDF
Abstract
► Mas-related gene GPCR (Mrg) are uniquely expressed in dorsal root ganglia. ► Intrathecal Mrg agonist BAM8-22 does not change pain sensitivity. ► I.t. BAM8-22 decreased tail flick latency following treatment with pertussis toxin. ► BAM8-22 decreased pain sensitivity in the presence of U73122. ► The first study to show association of Mrg receptors with Gi/o and Gq proteins in vivo.
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