Article ID Journal Published Year Pages File Type
6284106 Neuroscience Letters 2012 5 Pages PDF
Abstract
► Repeated exposure to cocaine can alter the subsequent rewarding effects of this drug. ► High-dose cocaine pretreatment decreases low-dose cocaine-induced CPP in mice. ► High doses of cocaine induce subsequent alterations in the brain reward system.
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Related Topics
Life Sciences Neuroscience Neuroscience (General)
Preview
Pre-treatment with high doses of cocaine decreases the reinforcing effects of cocaine in the conditioned place preference paradigm
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