Involvement of neuronal nitric oxide synthase in cognitive impairment in isoflurane-treated rats

Article ID	Journal	Published Year	Pages	File Type
6284319	Neuroscience Letters	2012	5 Pages	PDF

Abstract

âº Isoflurane impaired the cognitive functions of aged rats. âº Isoflurane down-regulated the nNOS expression in the hippocampus in aged rats. âº Hippocampal nNOS may involve in mechanism of isoflurane-induced cognitive impairment.

Keywords

ABC HSP 90 HSP 70 Sao2 POCD calcium/calmodulin-dependent protein kinase II alpha PaCO2 CaMKIIα nNOS PSD-95 N-methyl-d-aspartate NMDA CREB DAB PBS TRT BSA cAMP Cyclic adenosine monophosphate bovine serum albumin Postoperative cognitive dysfunction standard deviation Isoflurane analysis of variance ANOVA Y-maze test diaminobenzidine CAM neuronal nitric oxide synthase dentate gyrus Heart rate Cognitive function Phosphate buffered saline mean arterial blood pressure avidin–biotin–peroxidase complex respiratory rate map Nitric oxide Hippocampus heat shock protein 70 Heat shock protein 90 postsynaptic density protein 95 Calmodulin